Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362714 | 0.84 | ABL1 (0.45) | MAPTMAPK1ABL1NTRK1YES1 | |
| SCHEMBL3359607 | 0.84 | KDR (0.41) | MAPTMAPK1ABL1NTRK1YES1 | |
| SCHEMBL3360279 | 0.83 | ABL1 (0.41) | MAPTMAPK1ABL1NTRK1YES1 | |
| SCHEMBL3358758 | 0.81 | SYK (0.44) | MAPTMAPK1PKMYT1ZAP70JAK2 | |
| SCHEMBL3358312 | 0.81 | MAPT (0.46) | MAPTMAPK1ABL1KDRZAP70 | |
| SCHEMBL3359647 | 0.81 | MAPT (0.43) | MAPTMAPK1ZAP70TP53SYK | |
| SCHEMBL3362709 | 0.81 | SYK (0.45) | MAPTMAPK1PKMYT1ZAP70TP53 | |
| SCHEMBL3362463 | 0.80 | ZAP70 (0.49) | MAPTMAPK1PKMYT1ZAP70JAK2 | |
| SCHEMBL3362540 | 0.80 | SYK (0.44) | MAPTMAPK1ABL1NTRK1YES1 | |
| SCHEMBL3358598 | 0.80 | SYK (0.43) | MAPTMAPK1ABL1KDRZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |