Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | ILK | Q13418 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359502 | 0.90 | ZAP70 (0.43) | SRCSYKEGFRJAK2ILK | |
| SCHEMBL3359957 | 0.84 | SYK (0.43) | SRCSYKEGFRJAK2KDR | |
| SCHEMBL3359360 | 0.83 | SYK (0.40) | SRCSYKEGFRJAK2RAF1 | |
| SCHEMBL3362294 | 0.82 | BCHE (0.45) | SRCSYKEGFRJAK2KDR | |
| SCHEMBL3358208 | 0.82 | TLR9 (0.40) | EGFRAXLBACE1TGFBR1JAK2 | |
| SCHEMBL3359372 | 0.80 | TGFBR1 (0.40) | SYKEGFRTGFBR1JAK2JAK3 | |
| SCHEMBL1045675 | 0.79 | ZAP70 (0.55) | SRCSYKEGFRAXLBACE1 | |
| SCHEMBL3359920 | 0.79 | IGF1R (0.39) | SYKEGFRKDR | |
| SCHEMBL3362284 | 0.79 | ZAP70 (0.39) | SYKTGFBR1JAK2KDREPHA2 | |
| SCHEMBL3360194 | 0.78 | SRC (0.46) | SRCSYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |