⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221301 | 0.89 | SLC6A4 (0.33) | — | |
| SCHEMBL1851488 | 0.89 | SLC6A4 (0.33) | — | |
| SCHEMBL2447410 | 0.89 | SLC6A4 (0.33) | — | |
| SCHEMBL28177299 | 0.80 | ADH1A (0.32) | — | |
| SCHEMBL29024656 | 0.80 | ADH1A (0.32) | — | |
| SCHEMBL28178187 | 0.80 | ADH1A (0.32) | — | |
| SCHEMBL3316113 | 0.78 | HSD11B1 (0.31) | — | |
| SCHEMBL3852707 | 0.78 | — | — | |
| SCHEMBL385268 | 0.78 | — | — | |
| SCHEMBL5665104 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987560-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2024-05-21 | — | — | US | disclosed |
| EP-3496721-B1 | TREATMENT OF MERKEL CELLL CARCINOMA | CELGENE QUANTICEL RES INC (US) | 2023-12-06 | — | — | EP | disclosed |
| EP-4286381-A2 | TREATMENT OF MERKEL CELLL CARCINOMA | Celgene Quanticel Research, Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| US-20220153706-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2022-05-19 | — | — | US | disclosed |
| EP-3137169-B1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RES INC (US) | 2021-11-10 | — | — | EP | disclosed |
| US-11084793-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-11028066-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-10960005-B2 | Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas | CELGENE QUANTICEL RESEARCH, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| EP-3371152-B1 | COMPOSITIONS COMPRISING AN INHIBITOR OF LYSINE SPECIFIC DEMETHYLASE-1 HAVING A PYRIMIDINE RING AND ITS USE IN THE TREATMENT OF CANCER | CELGENE QUANTICEL RES INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-10849898-B2 | Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20060084688-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | BARTA THOMAS E | 2006-04-20 | — | — | US | disclosed |
| US-6890937-B2 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION (US) | 2005-05-10 | — | — | US | disclosed |
| WO-2005040159-A1 | 4-(PYRAZOL-3-YLAMINO) PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |
| US-6750233-B2 | SELECTIVITY | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-20040048852-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-03-11 | — | — | US | disclosed |
| US-6541489-B1 | Excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP- 1 | G. D. SEARLE & COMPANY | 2003-04-01 | — | — | US | disclosed |
| US-20020177588-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2002-11-28 | — | — | US | disclosed |
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | PHARMACIA CORPORATION | 2001-11-08 | — | — | US | disclosed |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | BARTA THOMAS E (US) | 2001-08-16 | — | — | US | disclosed |