Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 14/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361678 | 0.81 | ZAP70 (0.42) | ZAP70 | |
| SCHEMBL3359641 | 0.77 | ZAP70 (0.41) | ZAP70 | |
| SCHEMBL1048713 | 0.77 | ZAP70 (0.61) | IMPDH2BRAFZAP70 | |
| SCHEMBL3362965 | 0.77 | ZAP70 (0.55) | ZAP70 | |
| SCHEMBL3359055 | 0.76 | ZAP70 (0.40) | ZAP70 | |
| SCHEMBL3361841 | 0.74 | LRRK2 (0.39) | ZAP70 | |
| SCHEMBL3362887 | 0.74 | ZAP70 (0.46) | ZAP70 | |
| SCHEMBL1158541 | 0.74 | ZAP70 (0.49) | ZAP70 | |
| SCHEMBL3359688 | 0.73 | CHEK1 (0.40) | ABCG2ABCB1ABCC1 | |
| SCHEMBL1158133 | 0.73 | ZAP70 (0.48) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |