Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1049152 | 0.79 | ZAP70 (0.49) | CHEK1JAK2JAK3PTK2 | |
| SCHEMBL3360357 | 0.78 | ALK (0.39) | JAK2JAK3PTK2EGFRALK | |
| SCHEMBL3358854 | 0.77 | ALK (0.53) | JAK2JAK3PTK2EGFRALK | |
| SCHEMBL3359794 | 0.77 | JAK2 (0.38) | JAK2JAK3PTK2ALK | |
| SCHEMBL3359641 | 0.74 | ZAP70 (0.41) | JAK2JAK3PTK2TGFBR1ACVR1 | |
| SCHEMBL3362356 | 0.73 | BTK (0.38) | JAK2JAK3PTK2ALK | |
| SCHEMBL3359667 | 0.73 | IMPDH2 (0.40) | ABCB1ABCC1ABCG2 | |
| SCHEMBL3362371 | 0.73 | SYK (0.38) | — | |
| SCHEMBL3359627 | 0.73 | MAP4K1 (0.42) | JAK2PTK2EGFRALK | |
| SCHEMBL3360058 | 0.72 | JAK3 (0.40) | JAK2JAK3PTK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |