Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | CD63 | P08962 | 2/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.43 |
| ▸ | NRP1 | O14786 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362540 | 0.86 | SYK (0.44) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3358758 | 0.85 | SYK (0.44) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3358312 | 0.84 | MAPT (0.46) | PIK3CASYKCD63ZAP70AURKA | |
| SCHEMBL3358598 | 0.84 | SYK (0.43) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3362709 | 0.81 | SYK (0.45) | PIK3CASYKCD63ZAP70AURKA | |
| SCHEMBL3359647 | 0.81 | MAPT (0.43) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3360279 | 0.80 | ABL1 (0.41) | PIK3CASYKCD63ZAP70AURKA | |
| SCHEMBL3358704 | 0.80 | PIK3CA (0.44) | PIK3CASYKCD63ZAP70PIK3R1 | |
| SCHEMBL3361347 | 0.80 | ZAP70 (0.42) | SYKCD63ZAP70MTORAURKA | |
| SCHEMBL3362714 | 0.80 | ABL1 (0.45) | PIK3CASYKCD63ZAP70MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |