Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CD63 | P08962 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | PKMYT1 | Q99640 | 4/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359805 | 0.91 | ZAP70 (0.42) | SYKAURKAPIK3CAZAP70CD63 | |
| SCHEMBL3362714 | 0.90 | ABL1 (0.45) | SYKAURKAPIK3CAZAP70CD63 | |
| SCHEMBL3361347 | 0.90 | ZAP70 (0.42) | SYKAURKAZAP70IGF1RCD63 | |
| SCHEMBL3358764 | 0.85 | SYK (0.42) | SYKAURKAPIK3CAZAP70CD63 | |
| SCHEMBL3362308 | 0.85 | JAK2 (0.46) | SYKAURKAZAP70CD63MAPT | |
| SCHEMBL3360215 | 0.83 | PTK2 (0.39) | SYKPIK3CAZAP70 | |
| SCHEMBL3358985 | 0.83 | ZAP70 (0.43) | AURKAZAP70IGF1RTP53MAPT | |
| SCHEMBL3358758 | 0.82 | SYK (0.44) | SYKAURKAZAP70IGF1RCD63 | |
| SCHEMBL3358248 | 0.82 | ZAP70 (0.44) | SYKZAP70TP53MAPTMAPK1 | |
| SCHEMBL3359647 | 0.82 | MAPT (0.43) | SYKAURKAZAP70IGF1RCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |