Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | CD63 | P08962 | 2/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362540 | 0.87 | SYK (0.44) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3358598 | 0.87 | SYK (0.43) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3358312 | 0.86 | MAPT (0.46) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3359692 | 0.85 | PIK3CA (0.45) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3359647 | 0.84 | MAPT (0.43) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3360279 | 0.83 | ABL1 (0.41) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3362709 | 0.82 | SYK (0.45) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3358947 | 0.81 | CYP2C19 (0.40) | SYKZAP70AURKAMAPTTP53 | |
| SCHEMBL3361347 | 0.81 | ZAP70 (0.42) | SYKCD63ZAP70AURKAMAPT | |
| SCHEMBL3362714 | 0.81 | ABL1 (0.45) | SYKCD63ZAP70AURKAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |