Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 3/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12327069 | 0.84 | MEN1 (0.37) | MEN1KMT2AMAPTNPC1POLB | |
| SCHEMBL7974742 | 0.79 | DRD4 (0.43) | MEN1KMT2AMAPTNPC1POLB | |
| SCHEMBL2433489 | 0.79 | DRD4 (0.43) | MEN1KMT2AMAPTNPC1POLB | |
| SCHEMBL2431451 | 0.79 | MEN1 (0.42) | MEN1KMT2AMAPTNPC1POLB | |
| SCHEMBL3363237 | 0.72 | MGAM (0.45) | MEN1KMT2ANPC1RAB9AKMO | |
| SCHEMBL2433048 | 0.70 | ALDH1A1 (0.43) | KMOMGAMAMY1AGAASI | |
| SCHEMBL634176 | 0.70 | HSD17B3 (0.55) | MEN1KMT2ANPC1RAB9AKMO | |
| SCHEMBL9337894 | 0.69 | THRA (0.59) | KMOHDAC4HDAC1HDAC7HDAC11 | |
| SCHEMBL14166820 | 0.69 | TP53 (0.41) | POLBRAB9AALDH1A1 | |
| SCHEMBL2435064 | 0.69 | KDM4E (0.57) | KMOHDAC4HDAC1HDAC7HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011302-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2010-01-28 | — | — | WO | claimed |