SCHEMBL336072

SCHEMBL336072

Nc1nc2c(c(=O)[nH]1)NCN2COC(O)CCO

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 9/20 0.55
PNP P00491 3/20 0.34
BLM P54132 3/20 0.34
ALDH1A1 P00352 2/20 0.34
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
CYP3A4 P08684 1/20 0.34
NFKB1 P19838 1/20 0.34
VCP P55072 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HIF1A Q16665 1/20 0.34
USP2 O75604 2/20 0.33
HSD17B10 Q99714 2/20 0.33
NOS1 P29475 2/20 0.33
CASP7 P55210 1/20 0.33
PAH P00439 1/20 0.33
TSHR P16473 1/20 0.33
EDNRA P25101 1/20 0.33
HTR2A P28223 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL10601101 0.99 HPRT1 (0.54) HPRT1PNPBLMALDH1A1KMT2A
Ammonia Solution, Strong SCHEMBL10901621 0.99 HPRT1 (0.54) HPRT1PNPBLMALDH1A1KMT2A
Phosphoric Acid SCHEMBL9471917 0.96 HPRT1 (0.59) HPRT1PNPBLMALDH1A1KMT2A
SCHEMBL60630 0.91 HPRT1 (0.57) HPRT1BLMALDH1A1KMT2AMEN1
SCHEMBL147641 0.84 HPRT1 (0.67) HPRT1PNPBLMALDH1A1KMT2A
SCHEMBL2775722 0.84 HPRT1 (0.55) HPRT1BLMALDH1A1KMT2AMEN1
SCHEMBL7132437 0.83 HPRT1 (0.60) HPRT1PNPBLMALDH1A1KMT2A
Ganciclovir SCHEMBL8689225 0.83 BLM (0.65) HPRT1PNPBLMALDH1A1KMT2A
SCHEMBL10970955 0.82 HPRT1 (0.47) HPRT1PNPBLMALDH1A1KMT2A
SCHEMBL10919055 0.82 HPRT1 (0.58) HPRT1PNPBLMALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 463 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2851368-B1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU WDS FARMA (RU) 2019-01-02 EP claimed
US-9745337-B2 Complex compounds of germanium, methods for producing same, and drugs OBSCHESNO S OGRANICHENNOI OTVETSTVENNOSTYU “WDS FARMA” (RU) 2017-08-29 US claimed
US-20150126726-A1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "WDS FARMA" (RU) 2015-05-07 US claimed
EP-2851368-A1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS Obschestvo S Ogranichennoi Otvetstvennostyu "WDS FARMA" (RU) 2015-03-25 EP claimed
CN-104302651-A Germanium complex, process for producing the same and pharmaceutical OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU WDS FARMA 2015-01-21 CN claimed
EP-1146881-B1 PREPARATION FOR THE PREVENTION AND/OR TREATMENT OF A TISSUE CHANGE OF MESENCHYMAL ORIGIN BULLERDIEK JOERN (DE) 2006-01-04 EP claimed
US-20020147175-A1 Synergistic ECTA compositions NEWBIOTICS, INC. 2002-10-10 US claimed
WO-2002069949-A2 COMBINATION THERAPY FOR REDUCTION OF TOXYCITY OF CHEMOTHERAPEUTIC AGENTS PRENDERGAST PATRICK T (IE) 2002-09-12 WO claimed
WO-2002039952-A2 SYNERGISTIC ECTA COMPOSITIONS NEWBIOTICS, INC. (US) 2002-05-23 WO claimed
US-6015573-A TREATMENT OF RESISTANT HERPES VIRUS WITH NUCLEOSIDE PHOSPHATE ESTERS RESOLUTION PERFORMANCE PRODUCTS LLC 2000-01-18 US claimed
US-5879700-A TREATING HERPES VIRUS INFECTIONS HOSTETLER KARL Y (US) 1999-03-09 US claimed
EP-0746319-A4 ACYCLOVIR DERIVATIVES FOR TOPICAL USE HOSTETLER KARL Y (US) 1997-11-05 EP claimed
US-5648489-A PREPARING 9-((1,3-DIHYDROXY-2-PROPOXY)METHYL)GUANINE FROM A PROTECTED GUANINE AND 2-ACETOXYMETHOXY-1,3-DIACETOXYPROPANE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) 1997-07-15 US claimed
EP-0746319-A1 ACYCLOVIR DERIVATIVES FOR TOPICAL USE HOSTETLER, Karl Y. (US) 1996-12-11 EP claimed
WO-1994026273-A1 ACYCLOVIR DERIVATIVES FOR TOPICAL USE HOSTETLER KARL Y (US) 1994-11-24 WO claimed
US-5336770-A Transglycosilation process for producing acyclic nucleosides AJINOMOTO CO., INC. (JP) 1994-08-09 US claimed
US-12383558-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections EMORY UNIVERSITY (US) 2025-08-12 US disclosed
EP-4556010-A2 JAK INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF A VIRAL DISEASE CAUSED BY A CORONAVIRIDAE Emory University (US) 2025-05-21 EP disclosed
US-4565868-A PHOSPHORYLATION, ESTERIFICATION TO PRODUCE PHOSPHATE ESTERS SYNTEX (U.S.A.) INC. (US) 1986-01-21 US disclosed
EP-0138656-A1 Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides, their preparation and their application in anti-viral compositions MERCK & CO. INC. (US) 1985-04-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147175-A1 Synergistic ECTA compositions ENTPD1, ENTPD2, ENPP1 HPRT1 380/4885PNP 45/4885BLM 1208/4885
US-12383558-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections JAK1, JAK3, PNP HPRT1 17/4885PNP 3/4885BLM 4565/4885
US-20150126726-A1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS GDA, ATIC, AGXT HPRT1 96/4885PNP 65/4885BLM 4123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.