Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.82 |
| ▸ | INSR | P06213 | 4/20 | 0.69 |
| ▸ | IGF1R | P08069 | 4/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.67 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.64 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 6/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | RECQL | P46063 | 3/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | EIF4E | P06730 | 1/20 | 0.62 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12989661 | 1.00 | TTR (0.82) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL30657767 | 1.00 | TTR (0.82) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL3360964 | 1.00 | TTR (0.82) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL12156076 | 0.90 | TTR (1.00) | TTRINSRIGF1RPIK3CGPTPN5 | |
| SCHEMBL6387049 | 0.88 | INSR (0.82) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL6387045 | 0.88 | INSR (0.82) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL3892565 | 0.88 | HSPD1 (0.71) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL3892559 | 0.88 | HSPD1 (0.71) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL5124788 | 0.87 | IGF1R (0.80) | TTRINSRIGF1RPIK3CGPTP4A3 | |
| SCHEMBL14277839 | 0.87 | IGF1R (0.80) | TTRINSRIGF1RPIK3CGPTP4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331315-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-12-30 | — | — | US | disclosed |
| WO-2010148351-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331315-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | PIM2, PIM1, CDK2 | TTR 4754/4885INSR 1642/4885IGF1R 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.