⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11297558 | 0.94 | FKBP5 (0.31) | — | |
| SCHEMBL25292770 | 0.66 | — | — | |
| SCHEMBL23330237 | 0.63 | OR51E2 (0.31) | — | |
| SCHEMBL336274 | 0.60 | CA1 (0.32) | — | |
| SCHEMBL3518015 | 0.59 | OR51E2 (0.37) | — | |
| SCHEMBL13775942 | 0.58 | FKBP5 (0.34) | — | |
| SCHEMBL24435657 | 0.58 | — | — | |
| SCHEMBL1000742 | 0.57 | FKBP5 (0.33) | — | |
| SCHEMBL18638307 | 0.55 | OR51E2 (0.32) | — | |
| SCHEMBL18528198 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097632-B2 | Blocking hedgehog protein transduction signal passageway using alkaloid steroid | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-01-17 | — | — | US | claimed |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2008-03-06 | — | — | US | claimed |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-29 | — | — | US | claimed |
| US-20060020020-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2006-01-26 | — | — | US | claimed |
| US-20040127474-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2004-07-01 | — | — | US | claimed |
| US-6432970-B2 | REDUCE CELL SENSITIVITY | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2002-08-13 | — | — | US | claimed |
| JP-2002511415-A | — | — | 2002-04-16 | — | — | JP | claimed |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | THE JOHNS HOPKINS UNIVERSITY | 2002-01-17 | — | — | US | claimed |
| US-20010034337-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. | 2001-10-25 | — | — | US | claimed |
| EP-1143961-A2 | REGULATORS OF THE PTC OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Ontogeny, Inc. (US) | 2001-10-17 | — | — | EP | claimed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | claimed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | claimed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | claimed |
| EP-1387674-B1 | HEDGEHOG ANTAGONISTS, METHODS AND USES RELATED THERETO | CURIS INC (US) | 2017-01-18 | — | — | EP | disclosed |
| US-9440988-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-09-13 | — | — | US | disclosed |
| US-9427431-B2 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-08-30 | — | — | US | disclosed |
| WO-2001027135-A2 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2001-04-19 | — | — | WO | disclosed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | disclosed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | disclosed |