Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19203706 | 0.73 | — | — | |
| SCHEMBL18528198 | 0.67 | — | — | |
| SCHEMBL2616124 | 0.64 | — | — | |
| SCHEMBL23330237 | 0.63 | OR51E2 (0.31) | — | |
| SCHEMBL336101 | 0.60 | — | — | |
| SCHEMBL3518015 | 0.59 | OR51E2 (0.37) | — | |
| SCHEMBL13775942 | 0.58 | FKBP5 (0.34) | — | |
| SCHEMBL24435657 | 0.58 | — | — | |
| SCHEMBL18577008 | 0.58 | OR51E2 (0.35) | — | |
| SCHEMBL1000742 | 0.57 | FKBP5 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097632-B2 | Blocking hedgehog protein transduction signal passageway using alkaloid steroid | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-01-17 | — | — | US | claimed |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2008-03-06 | — | — | US | claimed |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-29 | — | — | US | claimed |
| US-20060020020-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2006-01-26 | — | — | US | claimed |
| US-20040127474-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2004-07-01 | — | — | US | claimed |
| US-6432970-B2 | REDUCE CELL SENSITIVITY | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2002-08-13 | — | — | US | claimed |
| JP-2002511415-A | — | — | 2002-04-16 | — | — | JP | claimed |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | THE JOHNS HOPKINS UNIVERSITY | 2002-01-17 | — | — | US | claimed |
| US-20010034337-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. | 2001-10-25 | — | — | US | claimed |
| EP-1143961-A2 | REGULATORS OF THE PTC OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Ontogeny, Inc. (US) | 2001-10-17 | — | — | EP | claimed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | claimed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | claimed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | claimed |
| CN-117903152-A | (E) -5,6,7, 8-tetrahydropyran pyridine-3-methyl formate derivative and preparation method and application thereof | 西华大学 | 2024-04-19 | — | — | CN | disclosed |
| EP-1387674-B1 | HEDGEHOG ANTAGONISTS, METHODS AND USES RELATED THERETO | CURIS INC (US) | 2017-01-18 | — | — | EP | disclosed |
| US-9440988-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-09-13 | — | — | US | disclosed |
| WO-2001027135-A2 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2001-04-19 | — | — | WO | disclosed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | disclosed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020020-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, GLI1, SMO | CA1 904/4885CA9 1758/4885 |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | CA1 1155/4885CA9 2882/4885 |
| US-20010034337-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, SMO, GLI1 | CA1 892/4885CA9 1777/4885 |
| US-20040127474-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, GLI1, SMO | CA1 904/4885CA9 1758/4885 |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | SHH, GLI1, SMO | CA1 1271/4885CA9 2935/4885 |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | SHH, GLI1, SMO | CA1 1230/4885CA9 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.