Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361081 | 0.88 | SYK (0.48) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL3359888 | 0.85 | ZAP70 (0.41) | SYKZAP70MAP4K1 | |
| SCHEMBL1046447 | 0.82 | ZAP70 (0.61) | SYKZAP70 | |
| SCHEMBL27806205 | 0.81 | SYK (0.45) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL3358971 | 0.78 | ZAP70 (0.47) | ZAP70JAK2JAK3PTK2BRD4 | |
| SCHEMBL3359025 | 0.77 | SYK (0.42) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL3358710 | 0.77 | JAK2 (0.45) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL3360687 | 0.77 | ZAP70 (0.47) | ZAP70BRD4MAP4K1 | |
| SCHEMBL3363124 | 0.76 | ZAP70 (0.46) | ZAP70BRD4MAP4K1 | |
| SCHEMBL3360211 | 0.76 | JAK2 (0.41) | SYKJAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |