Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 7/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359025 | 0.91 | SYK (0.42) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL3359635 | 0.85 | ZAP70 (0.53) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL3360058 | 0.85 | JAK3 (0.40) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL3360308 | 0.83 | SYK (0.44) | JAK3ZAP70SYKGPR119 | |
| SCHEMBL3360029 | 0.83 | PTK2 (0.42) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL3362704 | 0.82 | ZAP70 (0.40) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL3358971 | 0.81 | ZAP70 (0.47) | JAK2PTK2JAK3ZAP70CYP3A4 | |
| SCHEMBL3361735 | 0.80 | SYK (0.40) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL3360670 | 0.79 | ZAP70 (0.48) | JAK2PTK2JAK3ZAP70SYK | |
| SCHEMBL1048361 | 0.79 | JAK2 (0.47) | JAK2PTK2JAK3ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |