Pentamidine

Pentamidine

SCHEMBL33615

N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1.O=S(=O)(O)CCO.O=S(=O)(O)CCO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 1.00
LMNA P02545 2/20 1.00
POLB P06746 2/20 1.00
RAB9A P51151 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
NPC1 O15118 1/20 1.00
MAPT P10636 1/20 1.00
ALOX15 P16050 1/20 1.00
BRCA1 P38398 1/20 1.00
HTT P42858 1/20 1.00
KDM4E B2RXH2 1/20 1.00
GMNN O75496 1/20 1.00
PKM P14618 1/20 1.00
THPO P40225 1/20 1.00
MTOR P42345 1/20 1.00
RECQL P46063 1/20 1.00
BLM P54132 1/20 1.00
HIF1A Q16665 1/20 1.00
PRMT1 Q99873 3/20 0.69
F2 P00734 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hexamidine SCHEMBL985947 1.00 ALDH1A1 (1.00) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Hexamidine SCHEMBL128384 1.00 ALDH1A1 (1.00) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL27719324 1.00 ALDH1A1 (1.00) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL19462606 0.99 ALDH1A1 (0.97) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL5014184 0.99 ALDH1A1 (0.97) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL2658011 0.97 ALDH1A1 (0.95) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL23063972 0.96 ALDH1A1 (0.92) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Propamidine SCHEMBL293021 0.96 ALDH1A1 (0.92) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL16050177 0.94 ALDH1A1 (0.88) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2
Pentamidine SCHEMBL18007221 0.94 ALDH1A1 (0.88) ALDH1A1LMNAPOLBRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4293 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4631514-A1 ORAL POLYPEPTIDE COMPOSITION AND USE THEREOF Hefei Tianhui Biotech Co., Ltd. (CN) 2025-10-15 EP claimed
US-20250281579-A1 Methods and Compositions for Oral Administration of Proteins ORAMED PHARMACEUTICALS INC (IL) 2025-09-11 US claimed
EP-3976197-B1 THERAPEUTICS AND METHODS FOR PREDICTING AND OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER LUNELLA BIOTECH INC (CA) 2025-07-16 EP claimed
WO-2025111413-A1 TREATMENT FOR SKIN DISORDERS Mycotechnology, Inc. (US) 2025-05-30 WO claimed
US-12274830-B2 Nitric oxide inhalation therapy for infants with bronchiolitis BEYOND AIR LTD (IL) 2025-04-15 US claimed
CN-119742019-A Method for relieving noise nerve injury and application thereof 中国人民解放军军事科学院军事医学研究院 2025-04-01 CN claimed
CN-111183360-B Biomarker combinations for simultaneous assessment of non-alcoholic steatohepatitis and liver fibrosis status 生物辐射欧洲有限公司 2024-10-18 CN claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
CN-116080114-B Preparation method of biaxially oriented PDCPD film 四川东方绝缘材料股份有限公司 2024-07-02 CN claimed
WO-1991015201-A1 METHOD OF TREATING DISEASES ASSOCIATED WITH ELEVATED LEVELS OF INTERLEUKIN 1 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) 1991-10-17 WO claimed
EP-0345926-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING PENTAMIDINE FISONS CORPORATION (US) 1991-08-07 EP claimed
EP-0364559-A4 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS 1991-01-09 EP claimed
EP-0364559-A1 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS. SCRIPPS CLINIC RES (US) 1990-04-25 EP claimed
EP-0345926-A1 Pharmaceutical compositions containing pentamidine FISONS CORPORATION (US) 1989-12-13 EP claimed
WO-1989008658-A1 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1989-09-21 WO claimed
US-4853416-A TREATING PNEUMO-CYSTIS CARINII PNEUMONIA; AIDS; FISONS CORPORATION (GB) 1989-08-01 US claimed
EP-0315467-A2 Pentamidine salts useful in the treatment and prophylaxis of pneumocystis carinii pneumonia LyphoMed, Inc. (US) 1989-05-10 EP claimed
US-4823784-A Aerosol inhalation apparatus CADEMA MEDICAL PRODUCTS, INC. (US) 1989-04-25 US claimed
EP-0292100-A1 Composition for the prophylaxis or treatment of pneumocystis carinii pneumonia Sloan-Kettering Institute For Cancer Research (US) 1988-11-23 EP claimed