Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 13/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360354 | 0.90 | MAP4K1 (0.41) | MAP4K1ZAP70BRD4EGFRBTK | |
| SCHEMBL3362901 | 0.90 | MAP4K1 (0.44) | MAP4K1ZAP70BRD4EGFR | |
| SCHEMBL3358348 | 0.87 | ZAP70 (0.41) | MAP4K1ZAP70BRD4BTKMAP4K3 | |
| SCHEMBL3362296 | 0.84 | ZAP70 (0.49) | MAP4K1ZAP70BRD4MAP4K3 | |
| SCHEMBL3359724 | 0.83 | ZAP70 (0.40) | MAP4K1ZAP70BRD4EGFRBTK | |
| SCHEMBL3360687 | 0.83 | ZAP70 (0.47) | MAP4K1ZAP70BRD4MAP4K3 | |
| SCHEMBL3361998 | 0.82 | ZAP70 (0.42) | MAP4K1ZAP70BRD4EGFRBTK | |
| SCHEMBL3359627 | 0.82 | MAP4K1 (0.42) | MAP4K1ZAP70BRD4EGFRBTK | |
| SCHEMBL3363125 | 0.81 | ZAP70 (0.49) | MAP4K1ZAP70BRD4MAP4K3 | |
| SCHEMBL3358746 | 0.81 | ZAP70 (0.43) | MAP4K1ZAP70BRD4EGFRMAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |