Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | NPM1 | P06748 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362622 | 0.90 | SYK (0.37) | MAP4K1EGFRBTKJAK2PTK2 | |
| SCHEMBL3362901 | 0.90 | MAP4K1 (0.44) | MAP4K1INSRZAP70MAPK7EGFR | |
| SCHEMBL3358417 | 0.88 | JAK2 (0.41) | MAP4K1ALKZAP70MAPK7EGFR | |
| SCHEMBL3358521 | 0.84 | ZAP70 (0.40) | MAP4K1INSRZAP70EGFRTNK2 | |
| SCHEMBL3357921 | 0.83 | ZAP70 (0.47) | MAP4K1ZAP70EGFRBRD4 | |
| SCHEMBL3362632 | 0.83 | ZAP70 (0.45) | MAP4K1ZAP70JAK2PTK2BRD4 | |
| SCHEMBL3361998 | 0.82 | ZAP70 (0.42) | MAP4K1ALKZAP70EGFRWEE1 | |
| SCHEMBL3359111 | 0.82 | ZAP70 (0.52) | MAP4K1ZAP70EGFRBRD4 | |
| SCHEMBL3361999 | 0.82 | MAP4K1 (0.51) | MAP4K1ZAP70EGFRBTKBRD4 | |
| SCHEMBL3359724 | 0.82 | ZAP70 (0.40) | MAP4K1ALKZAP70EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |