Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 3/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359787 | 0.90 | SLC18A3 (0.36) | ZAP70BRD4BTKKCNH2EML4 | |
| SCHEMBL3359006 | 0.90 | BTK (0.43) | ZAP70BRD4BTKEGFRJAK2 | |
| SCHEMBL3360902 | 0.90 | SYK (0.39) | ZAP70BRD4BTKEGFRJAK2 | |
| SCHEMBL3362321 | 0.89 | TGFBR1 (0.35) | ZAP70BRD4BTKKCNH2EGFR | |
| SCHEMBL3362356 | 0.89 | BTK (0.38) | ZAP70BRD4BTKALKWEE1 | |
| SCHEMBL3360034 | 0.88 | ZAP70 (0.45) | ZAP70EGFRWEE1 | |
| SCHEMBL3362295 | 0.86 | ZAP70 (0.41) | ZAP70BRD4BTKEML4ALK | |
| SCHEMBL3360687 | 0.85 | ZAP70 (0.47) | ZAP70BRD4MAP4K1 | |
| SCHEMBL3362296 | 0.84 | ZAP70 (0.49) | ZAP70BRD4MAP4K1 | |
| SCHEMBL3358746 | 0.83 | ZAP70 (0.43) | ZAP70BRD4EML4ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |