SCHEMBL3362091

SCHEMBL3362091

Cn1cc(-c2nc(Cl)nc(Cl)n2)c2ccccc21

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.63
POLB P06746 2/20 0.63
CTDSP1 Q9GZU7 1/20 0.63
ALDH1A1 P00352 3/20 0.50
NPSR1 Q6W5P4 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
NPC1 O15118 2/20 0.49
HPGD P15428 2/20 0.49
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
LMNA P02545 1/20 0.49
MAPT P10636 1/20 0.49
TSHR P16473 1/20 0.49
HTT P42858 1/20 0.49
HSD17B10 Q99714 1/20 0.49
CCNE2 O96020 1/20 0.47
CDK4 P11802 1/20 0.47
CCND1 P24385 1/20 0.47
CCNE1 P24864 1/20 0.47
CDK2 P24941 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24154737 0.87 KDM4E (0.50) KDM4EPOLBCTDSP1ALDH1A1NPSR1
SCHEMBL29025136 0.84 KDM4E (0.47) KDM4EPOLBCTDSP1ALDH1A1NPC1
SCHEMBL20549072 0.81 KDM4E (0.45) KDM4EPOLBCTDSP1ALDH1A1NPC1
SCHEMBL30337190 0.80 KDM4E (0.44) KDM4EPOLBCTDSP1ALDH1A1NPC1
SCHEMBL28987622 0.80 KDM4E (0.44) KDM4EPOLBCTDSP1ALDH1A1NPC1
SCHEMBL5096322 0.78 MKNK1 (0.50) KDM4EALDH1A1NPC1HPGDRAB9A
SCHEMBL29419125 0.78 MKNK1 (0.50) KDM4EALDH1A1NPC1HPGDRAB9A
SCHEMBL7266513 0.78 ALDH1A1 (0.49) KDM4EALDH1A1NPC1HPGDRAB9A
SCHEMBL29212194 0.78 BRD4 (0.48) KDM4EALDH1A1NPC1HPGDRAB9A
SCHEMBL23091480 0.78 KDM4E (1.00) KDM4EPOLBCTDSP1ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4169915-A1 CRYSTALLINE FORM OF COMPOUND Shenzhen Forward Pharmaceuticals Co., Limited (CN) 2023-04-26 EP disclosed
WO-2021259316-A1 CRYSTALLINE FORM OF COMPOUND 深圳福沃药业有限公司 2021-12-30 WO disclosed
EP-2210887-A1 Bis resorcinyl triazine derivatives as protecting agents against UV radiation ISDIN, S.A. (ES) 2010-07-28 EP disclosed