Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | WEE1 | P30291 | 2/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358388 | 0.88 | MAP3K12 (0.39) | TNK2BTKWEE1ZAP70IGF1R | |
| SCHEMBL3362356 | 0.85 | BTK (0.38) | TNK2BTKWEE1ZAP70IGF1R | |
| SCHEMBL3363275 | 0.83 | ZAP70 (0.38) | TNK2BTKWEE1ZAP70IGF1R | |
| SCHEMBL3359197 | 0.83 | ALK (0.34) | TNK2BTKIGF1RJAK3EGFR | |
| SCHEMBL3360064 | 0.83 | ACVR1 (0.34) | TNK2BTKWEE1IGF1RJAK3 | |
| SCHEMBL3362371 | 0.83 | SYK (0.38) | TNK2BTKWEE1ZAP70STK17A | |
| SCHEMBL3359641 | 0.82 | ZAP70 (0.41) | TNK2ZAP70JAK3SYKJAK2 | |
| SCHEMBL3358746 | 0.82 | ZAP70 (0.43) | WEE1ZAP70JAK3EGFRLCK | |
| SCHEMBL3359794 | 0.81 | JAK2 (0.38) | BTKWEE1ZAP70JAK3SYK | |
| SCHEMBL3360058 | 0.80 | JAK3 (0.40) | ZAP70JAK3SYKJAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |