Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359057 | 0.91 | SYK (0.41) | SYKALKZAP70 | |
| SCHEMBL3359025 | 0.87 | SYK (0.42) | JAK3PTK2SYKJAK2ALK | |
| SCHEMBL3358710 | 0.85 | JAK2 (0.45) | JAK3PTK2SYKJAK2ZAP70 | |
| SCHEMBL3362371 | 0.84 | SYK (0.38) | SYKZAP70 | |
| SCHEMBL3357802 | 0.83 | ALK (0.39) | JAK3SYKIKBKBJAK2ALK | |
| SCHEMBL3363275 | 0.83 | ZAP70 (0.38) | JAK3SYKZAP70 | |
| SCHEMBL3362286 | 0.82 | ALK (0.36) | JAK3SYKIKBKBJAK2ALK | |
| SCHEMBL3359859 | 0.82 | JAK3 (0.40) | JAK3PTK2SYKIKBKBCHUK | |
| SCHEMBL3362356 | 0.81 | BTK (0.38) | JAK3PTK2SYKJAK2ALK | |
| SCHEMBL3358388 | 0.80 | MAP3K12 (0.39) | JAK3SYKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |