Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | JAK3 | P52333 | 9/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359641 | 0.89 | ZAP70 (0.41) | JAK2JAK3PTK2ZAP70SYK | |
| SCHEMBL3362356 | 0.89 | BTK (0.38) | JAK2JAK3PTK2TYK2BTK | |
| SCHEMBL3358208 | 0.85 | TLR9 (0.40) | JAK2JAK3PTK2BTKZAP70 | |
| SCHEMBL3359055 | 0.84 | ZAP70 (0.40) | JAK2JAK3PTK2ZAP70SYK | |
| SCHEMBL3361810 | 0.84 | TLR9 (0.39) | JAK2JAK3PTK2BTKZAP70 | |
| SCHEMBL3360064 | 0.81 | ACVR1 (0.34) | JAK3TYK2BTKWEE1SYK | |
| SCHEMBL3358388 | 0.81 | MAP3K12 (0.39) | JAK3TYK2BTKWEE1ZAP70 | |
| SCHEMBL3362432 | 0.81 | TNK2 (0.38) | JAK2JAK3PTK2TYK2BTK | |
| SCHEMBL3362965 | 0.80 | ZAP70 (0.55) | WEE1ALKZAP70SYK | |
| SCHEMBL3358792 | 0.79 | ZAP70 (0.42) | JAK2WEE1ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |