Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368819 | 0.90 | LSS (0.51) | LSSL3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL3364497 | 0.90 | LSS (0.51) | LSSL3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL3367242 | 0.89 | PGR (0.52) | LSSL3MBTL1TDP1TP53 | |
| SCHEMBL3364934 | 0.89 | FFAR1 (0.52) | LSSL3MBTL1TDP1ALDH1A1LTA4H | |
| SCHEMBL3364755 | 0.89 | L3MBTL1 (0.51) | LSSL3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL7704977 | 0.89 | L3MBTL1 (0.62) | LSSL3MBTL1TDP1HPGDALDH1A1 | |
| SCHEMBL3362911 | 0.89 | L3MBTL1 (0.50) | LSSL3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL3363107 | 0.88 | LSS (0.48) | LSSL3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL3365132 | 0.87 | L3MBTL1 (0.53) | LSSL3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL3366906 | 0.86 | LSS (0.56) | LSSL3MBTL1TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| US-6683201-B2 | FOR THERAPY AND PROPHYLAXIS OF HYPERCHOLESTEROLEMIA, HYPERLIPEMIA, ARTERIOSCLEROSIS, VASCULAR DISEASES, MYCOSES, PARASITE INFECTIONS, GALLSTONES, TUMORS AND/OR HYPERPROLIFERATIVE DISORDERS, DIABETES | HOFFMANN-LA ROCHE INC. | 2004-01-27 | — | — | US | disclosed |