SCHEMBL3363422

SCHEMBL3363422

O=C(CCC(=O)N1CCC(O)CC1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 10/20 0.51
MCHR1 Q99705 3/20 0.49
SMN1; SMN2 Q16637 1/20 0.48
KMT2A Q03164 1/20 0.48
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
AGTR1 P30556 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3364246 0.92 ALDH1A1 (0.47) HRH3MCHR1SMN1; SMN2KMT2AALDH1A1
SCHEMBL3360999 0.88 ALDH1A1 (0.54) HRH3MCHR1SMN1; SMN2KMT2AALDH1A1
SCHEMBL7980593 0.87 TSHR (0.44) HRH3KMT2AALDH1A1LMNAAGTR1
SCHEMBL2433278 0.81 DRD4 (0.46) HRH3MCHR1KMT2AALDH1A1LMNA
SCHEMBL7974019 0.80 TSHR (0.42) KMT2AALDH1A1LMNAAGTR1HPGD
SCHEMBL8648284 0.77 SMN1; SMN2 (0.59) HRH3MCHR1SMN1; SMN2KMT2A
SCHEMBL14489806 0.76 MCHR1 (0.72) HRH3MCHR1SMN1; SMN2KMT2A
SCHEMBL8650355 0.76 KMT2A (0.51) HRH3SMN1; SMN2KMT2A
SCHEMBL7977776 0.75 ALDH1A1 (0.47) SMN1; SMN2KMT2AALDH1A1LMNAAGTR1
SCHEMBL11174620 0.74 PARP1 (0.50) ALDH1A1LMNAAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010011302-A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF CHDI, INC. (US) 2010-01-28 WO claimed
WO-2010011302-A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF CHDI, INC. (US) 2010-01-28 WO disclosed