Didanosine

Didanosine

SCHEMBL3364

OC[C@@H]1CC[C@H](n2cnc3c(O)ncnc32)O1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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The experimentally established mechanism targets of Didanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.61
LMNA P02545 1/20 0.61
ALB P02768 1/20 0.61
MAPK1 P28482 1/20 0.61
ABL1 P00519 2/20 0.48
RIN1 Q13671 2/20 0.48
ADA P00813 1/20 0.47
CYP1A2 P05177 1/20 0.47
HIF1A Q16665 1/20 0.45
TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Didanosine SCHEMBL1769151 1.00 ALDH1A1 (0.61) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL12150307 1.00 ALDH1A1 (0.61) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL7910803 0.99 ALDH1A1 (0.60) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL8709115 0.99 ALDH1A1 (0.60) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL7910809 0.99 ALDH1A1 (0.60) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL7907423 0.97 ALDH1A1 (0.59) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL7907418 0.97 ALDH1A1 (0.59) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL9223571 0.94 ALDH1A1 (0.56) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL8025110 0.94 ALDH1A1 (0.58) ALDH1A1LMNAALBMAPK1ABL1
Didanosine SCHEMBL9594496 0.93 ADA (0.58) ALDH1A1LMNAALBMAPK1ADA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11344 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
EP-4727950-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS GlaxoSmithKline Intellectual Property Development Ltd (GB) 2026-04-22 EP claimed
EP-3991729-B1 USE OF AMLEXANOX IN PREPARING ANTI-HEPATITIS VIRUS DRUG MARINE BIOMEDICAL RES INST QINGDAO CO LTD (CN) 2026-03-25 EP claimed
EP-4698174-A1 DOSING REGIMEN OF CAPSID INHIBITOR GILEAD SCIENCES, INC. (US) 2026-02-25 EP claimed
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US claimed
CN-120078775-A Capsid inhibitors for the treatment of HIV 吉利德科学公司 2025-06-03 CN claimed
CN-120053445-A Capsid inhibitors for the treatment of HIV 吉利德科学公司 2025-05-30 CN claimed
CN-120053447-A Capsid inhibitors for the treatment of HIV 吉利德科学公司 2025-05-30 CN claimed
EP-4547335-A2 ANTI-SARS-COV-2 ANTIGEN BINDING POLYPEPTIDES, POLYPEPTIDE COMPLEXES AND METHODS OF USE THEREOF Modex Therapeutics, Inc. (US) 2025-05-07 EP claimed
US-20250129084-A1 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2025-04-24 US claimed
WO-1989011274-A1 CHEMOTHERAPEUTIC COMPOSITION FOR AIDS THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH (US) 1989-11-30 WO claimed
WO-1989011277-A2 PORPHYRIN AND PHTHALOCYANINE ANTIVIRAL COMPOSITIONS GEORGIA STATE UNIVERSITY FOUNDATION, INC. (US) 1989-11-30 WO claimed
US-4861759-A Antiviral compositions and methods THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1989-08-29 US claimed
US-4835104-A Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides AJINOMOTO CO., INC., PATENT & LICENSING DEPARTMENT (JP) 1989-05-30 US claimed
EP-0312222-A1 Treatment of diseases caused by viruses Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) 1989-04-19 EP claimed
EP-0270317-A2 Pharmaceutical compositions for the treatment of diseases caused by viruses Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) 1988-06-08 EP claimed
US-4704357-A TESTING DRUGS FOR EFFICARY AGAINST AIDS VIRUS UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1987-11-03 US claimed
EP-0216510-A2 Inhibition of in vitro infectivity and cytopathic effect of HTLV-III/LAV by 2'3'-dideoxyinosine, 2'3'-dideoxyguanosine, or 2'3'-dideoxyadenosine THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1987-04-01 EP claimed
WO-1987001284-A1 INHIBITION OF IN VITRO INFECTIVITY AND CYTOPATHIC EFFECT OF HTLV-III/LAV BY 2',3'-DIDEOXYNOSINE, 2',3'-DIDEOXYGUANOSINE, OR 2',3'-DIDEOXYADENOSINE UNITED STATES OF AMERICA, REPRESENTED BY THE UNITE (US) 1987-03-12 WO claimed
EP-0206497-A2 Therapeutic nucleosides and their preparation THE WELLCOME FOUNDATION LIMITED (GB) 1986-12-30 EP claimed