Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Didanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.44 |
| ▸ | ADA | P00813 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Didanosine SCHEMBL29387997 | 0.94 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL12150307 | 0.94 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL3364 | 0.94 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL1769151 | 0.94 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL9223571 | 0.93 | ALDH1A1 (0.56) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL8709115 | 0.93 | ALDH1A1 (0.60) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL7910803 | 0.93 | ALDH1A1 (0.60) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL7910809 | 0.93 | ALDH1A1 (0.60) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL6066346 | 0.92 | ALDH1A1 (0.53) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL7907423 | 0.92 | ALDH1A1 (0.59) | ALDH1A1LMNAALBMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861759-A | Antiviral compositions and methods | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1989-08-29 | — | — | US | claimed |
| EP-0550646-B1 | IMPROVED NUCLEIC ACID SEQUENCE ANALYSIS WITH NUCLEOSIDE-5'-0-(1-THIOTRIPHOSPHATES) | PERKIN ELMER CORP (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5366860-A | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination | APPLIED BIOSYSTEMS, INC. (US) | 1994-11-22 | — | — | US | disclosed |
| EP-0550646-A4 | IMPROVED NUCLEIC ACID SEQUENCE ANALYSIS WITH NUCLEOSIDE-5'-0-(1-THIOTRIPHOSPHATES) | APPLIED BIOSYSTEMS (US) | 1994-05-25 | — | — | EP | disclosed |
| EP-0550646-A1 | IMPROVED NUCLEIC ACID SEQUENCE ANALYSIS WITH NUCLEOSIDE-5'-0-(1-THIOTRIPHOSPHATES) | THE PERKIN-ELMER CORPORATION (US) | 1993-07-14 | — | — | EP | disclosed |
| EP-0496749-A4 | SPECTRALLY RESOLVABLE RHODAMINE DYES FOR NUCLEIC ACID SEQUENCE DETERMINATION | — | 1993-06-16 | — | — | EP | disclosed |
| US-5187085-A | NUCLEIC ACID SEQUENCE ANALYSIS WITH NUCLEOSIDE-5'-O-(1-THIOTRIPHOSPHATES) | APPLIED BIOSYSTEMS, INC. (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0496749-A1 | SPECTRALLY RESOLVABLE RHODAMINE DYES FOR NUCLEIC ACID SEQUENCE DETERMINATION. | APPLIED BIOSYSTEMS (US) | 1992-08-05 | — | — | EP | disclosed |
| WO-1992006219-A1 | IMPROVED NUCLEIC ACID SEQUENCE ANALYSIS WITH NUCLEOSIDE-5'-0-(1-THIOTRIPHOSPHATES) | APPLIED BIOSYSTEMS, INC. (US) | 1992-04-16 | — | — | WO | disclosed |
| WO-1991005060-A2 | SPECTRALLY RESOLVABLE RHODAMINE DYES FOR NUCLEIC ACID SEQUENCE DETERMINATION | APPLIED BIOSYSTEMS, INC. (US) | 1991-04-18 | — | — | WO | disclosed |