Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206654 | 0.91 | CRHR1 (0.46) | CRHR1MEN1KMT2ACNR1 | |
| SCHEMBL3366726 | 0.90 | CRHR1 (0.45) | CRHR1MEN1KMT2ACNR1F2RL3 | |
| SCHEMBL3366050 | 0.89 | CRHR1 (0.46) | CRHR1MEN1KMT2ACNR1KDM4E | |
| SCHEMBL4697892 | 0.88 | CRHR1 (0.44) | CRHR1MEN1KMT2ACNR1KDM4E | |
| SCHEMBL3363935 | 0.88 | CRHR1 (0.44) | CRHR1MEN1KMT2ACNR1HTT | |
| SCHEMBL3364212 | 0.84 | CRHR1 (0.46) | CRHR1CNR1KDM4EF2RL3HSD11B1 | |
| SCHEMBL3367536 | 0.82 | CRHR1 (0.49) | CRHR1CNR1KDM4EMAPK1F2RL3 | |
| SCHEMBL3365373 | 0.81 | CRHR1 (0.46) | CRHR1CNR1 | |
| SCHEMBL3364275 | 0.80 | CRHR1 (0.58) | CRHR1F2RL3HSD11B1TNKS | |
| SCHEMBL14206630 | 0.80 | CRHR1 (0.49) | CRHR1KMT2ACNR1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |