SCHEMBL3364494

SCHEMBL3364494

COc1cc(O)cc2c1O[C@@H](c1ccccc1)CC2=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.65
MAPT P10636 2/20 0.65
KMT2A Q03164 2/20 0.65
POLB P06746 1/20 0.65
GAA P10253 1/20 0.65
PABPC1 P11940 1/20 0.65
APEX1 P27695 1/20 0.65
RECQL P46063 1/20 0.65
EIF4H Q15056 1/20 0.65
L3MBTL1 Q9Y468 1/20 0.65
CYP19A1 P11511 5/20 0.63
ABCG2 Q9UNQ0 5/20 0.59
ABCB1 P08183 3/20 0.59
AR P10275 2/20 0.56
MAOB P27338 2/20 0.53
MAOA P21397 1/20 0.53
PSMB5 P28074 1/20 0.53
HSD17B10 Q99714 3/20 0.53
KDM4E B2RXH2 2/20 0.53
ALDH1A1 P00352 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3368230 0.92 CYP19A1 (0.59) MEN1MAPTKMT2APOLBGAA
SCHEMBL14829728 0.86 CYP19A1 (0.65) MEN1MAPTKMT2APOLBGAA
SCHEMBL6503931 0.86 POLB (0.62) MEN1MAPTKMT2APOLBGAA
SCHEMBL2879029 0.86 ABCG2 (0.67) MEN1MAPTKMT2APOLBGAA
SCHEMBL17907269 0.84 MEN1 (0.67) MEN1MAPTKMT2APOLBGAA
SCHEMBL5085606 0.82 CYP19A1 (0.63) MEN1MAPTKMT2APOLBGAA
SCHEMBL1508800 0.82 CYP19A1 (0.64) MEN1MAPTKMT2APOLBGAA
SCHEMBL5084282 0.82 ABCG2 (0.68) MEN1MAPTKMT2APOLBGAA
SCHEMBL1242979 0.81 KDM4E (0.65) MEN1MAPTKMT2APOLBGAA
SCHEMBL1460823 0.81 HSD17B10 (0.76) MEN1MAPTKMT2APOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893173-B1 AMINO-OXO-INDOLE-YLIDENE COMPOUNDS FOR USE IN TREATING SCALP SKIN ITCHING UNILEVER PLC (GB) 2010-10-06 EP claimed
EP-2082726-A2 Hair and/or scalp care compositions incorporating flavonoid compounds Unilever PLC (GB) 2009-07-29 EP claimed
US-20080207928-A1 Hair and/or Scalp Care Compositions Incorporating Flavonoid Compounds CONOPCO, INC. D/B/A UNILEVER 2008-08-28 US claimed
EP-1893173-A1 HAIR AND/OR SCALP CARE COMPOSITIONS INCORPORATING AMINO-OXO-INDOLE-YLIDENE COMPOUNDS Unilever Plc (GB) 2008-03-05 EP claimed
WO-2006097191-A1 HAIR AND/OR SCALP CARE COMPOSITIONS INCORPORATING FLAVONOID COMPOUNDS UNILEVER PLC (GB) 2006-09-21 WO claimed
CN-115721671-A Method for extracting and separating effective components of liquorice root in full-industrial-chain cooperation manner 李玉山 2023-03-03 CN disclosed
EP-1893173-B1 AMINO-OXO-INDOLE-YLIDENE COMPOUNDS FOR USE IN TREATING SCALP SKIN ITCHING UNILEVER PLC (GB) 2010-10-06 EP disclosed
EP-2082726-A3 Hair and/or scalp care compositions incorporating flavonoid compounds Unilever PLC (GB) 2009-09-02 EP disclosed
EP-2082726-A2 Hair and/or scalp care compositions incorporating flavonoid compounds Unilever PLC (GB) 2009-07-29 EP disclosed
EP-2082726-A2 Hair and/or scalp care compositions incorporating flavonoid compounds Unilever PLC (GB) 2009-07-29 EP disclosed
US-7494673-B1 Method for treatment of kidney and/or urinary system stones TORRES PHILLIP 2009-02-24 US disclosed
US-20080207928-A1 Hair and/or Scalp Care Compositions Incorporating Flavonoid Compounds CONOPCO, INC. D/B/A UNILEVER 2008-08-28 US disclosed
WO-2007115181-A9 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEM CO (US) 2008-04-03 WO disclosed
EP-1893173-A1 HAIR AND/OR SCALP CARE COMPOSITIONS INCORPORATING AMINO-OXO-INDOLE-YLIDENE COMPOUNDS Unilever Plc (GB) 2008-03-05 EP disclosed
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof EASTMAN CHEMICAL COMPANY 2007-11-01 US disclosed
WO-2007115181-A2 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEMICAL COMPANY (US) 2007-10-11 WO disclosed
WO-2006097191-A1 HAIR AND/OR SCALP CARE COMPOSITIONS INCORPORATING FLAVONOID COMPOUNDS UNILEVER PLC (GB) 2006-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof ABCC4, NCOA4, NR4A3 MEN1 4281/4885MAPT 4566/4885KMT2A 4362/4885
US-20080207928-A1 Hair and/or Scalp Care Compositions Incorporating Flavonoid Compounds POLR1C, F3, AKR1C3 MEN1 1463/4885MAPT 2140/4885KMT2A 1698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.