Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368626 | 0.90 | PGR (0.53) | PGRL3MBTL1SMN1; SMN2MCOLN3FDPS | |
| SCHEMBL3365352 | 0.90 | PGR (0.53) | PGRL3MBTL1SMN1; SMN2MCOLN3FDPS | |
| SCHEMBL3366148 | 0.89 | FFAR1 (0.52) | L3MBTL1SMN1; SMN2FDPSRAB9AHPGD | |
| SCHEMBL3364755 | 0.89 | L3MBTL1 (0.51) | PGRL3MBTL1HPGDALDH1A1TP53 | |
| SCHEMBL3367242 | 0.89 | PGR (0.52) | PGRL3MBTL1SMN1; SMN2MCOLN3FDPS | |
| SCHEMBL7704534 | 0.89 | L3MBTL1 (0.66) | PGRL3MBTL1FDPSHPGDKMT2A | |
| SCHEMBL3362435 | 0.89 | PGR (0.54) | PGRL3MBTL1SMN1; SMN2MCOLN3FDPS | |
| SCHEMBL3363565 | 0.87 | PGR (0.57) | PGRL3MBTL1SMN1; SMN2MCOLN3NR2F2 | |
| SCHEMBL3364981 | 0.86 | L3MBTL1 (0.48) | L3MBTL1HPGDALDH1A1 | |
| SCHEMBL3367719 | 0.85 | LSS (0.52) | PGRL3MBTL1SMN1; SMN2MCOLN3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| US-6683201-B2 | FOR THERAPY AND PROPHYLAXIS OF HYPERCHOLESTEROLEMIA, HYPERLIPEMIA, ARTERIOSCLEROSIS, VASCULAR DISEASES, MYCOSES, PARASITE INFECTIONS, GALLSTONES, TUMORS AND/OR HYPERPROLIFERATIVE DISORDERS, DIABETES | HOFFMANN-LA ROCHE INC. | 2004-01-27 | — | — | US | disclosed |
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |