Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.86 |
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CD69 | Q07108 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | CA9 | Q16790 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31702246 | 1.00 | TRPA1 (0.86) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL70162 | 1.00 | TRPA1 (0.86) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL70163 | 1.00 | TRPA1 (0.86) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL29163841 | 0.97 | TRPA1 (0.82) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL28611366 | 0.97 | TRPA1 (0.82) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL28018222 | 0.97 | TRPA1 (0.82) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL28018294 | 0.97 | TRPA1 (0.82) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL20307199 | 0.93 | TRPA1 (1.00) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL168297 | 0.93 | TRPA1 (1.00) | TRPA1NPC1POLBKMT2AMEN1 | |
| SCHEMBL384410 | 0.93 | TRPA1 (1.00) | TRPA1NPC1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9326930-B2 | Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions | NEOCUTIS S.A. (CH) | 2016-05-03 | — | — | US | disclosed |
| US-20160030321-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | NEOCUITIS S A (CH) | 2016-02-04 | — | — | US | disclosed |
| US-20100189795-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | NEOCUTIS S.A. (CH) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100189795-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | S100A4, TYR, CACYBP | TRPA1 793/4885NPC1 840/4885POLB 3521/4885 |
| US-20160030321-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | S100A4, TYR, CACYBP | TRPA1 793/4885NPC1 840/4885POLB 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.