Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366157 | 0.87 | ROCK2 (0.60) | ROCK2HRH3HRH4 | |
| SCHEMBL720101 | 0.82 | ROCK2 (0.63) | ROCK2HRH4 | |
| SCHEMBL3364521 | 0.81 | ROCK2 (0.59) | ROCK2HRH4 | |
| SCHEMBL4390841 | 0.81 | HRH3 (0.45) | HRH3HRH4 | |
| SCHEMBL4401465 | 0.81 | HRH3 (0.45) | HRH3HRH4 | |
| SCHEMBL3365177 | 0.79 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL13115584 | 0.78 | ROCK1 (0.57) | ROCK2HRH4 | |
| SCHEMBL4396306 | 0.78 | HRH4 (0.46) | HRH3HRH4 | |
| SCHEMBL4402301 | 0.77 | HRH4 (0.50) | HRH3HRH4 | |
| SCHEMBL4393530 | 0.77 | HRH4 (0.50) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515965-B1 | PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2010-10-06 | — | — | EP | disclosed |
| EP-1515965-B1 | PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2010-10-06 | — | — | EP | disclosed |