Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390841 | 1.00 | HRH3 (0.45) | HRH3HRH4MAP4K4KCNH2 | |
| SCHEMBL4393530 | 0.89 | HRH4 (0.50) | HRH3HRH4MAP4K4KCNH2 | |
| SCHEMBL4402301 | 0.89 | HRH4 (0.50) | HRH3HRH4MAP4K4KCNH2 | |
| SCHEMBL4396306 | 0.89 | HRH4 (0.46) | HRH3HRH4MAP4K4 | |
| SCHEMBL4401308 | 0.84 | HRH4 (0.55) | HRH3HRH4KCNH2 | |
| SCHEMBL4395560 | 0.83 | HRH3 (0.46) | HRH3HRH4MAP4K4KCNH2 | |
| SCHEMBL4393818 | 0.83 | HRH4 (0.45) | HRH3HRH4MAP4K4KCNH2 | |
| SCHEMBL3364905 | 0.81 | ROCK2 (0.59) | HRH3HRH4 | |
| SCHEMBL27738427 | 0.78 | HRH4 (0.69) | HRH3HRH4 | |
| SCHEMBL8332861 | 0.76 | ROCK2 (0.75) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA, S.A. (ES) | 2009-12-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | HRH4, HRH2, HRH3 | HRH3 3/4885HRH4 1/4885MAP4K4 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.