Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367658 | 0.91 | EGLN1 (0.40) | ROCK2CYP2C9NR4A2EGLN1TP53 | |
| SCHEMBL3365504 | 0.80 | EGLN1 (0.48) | NPC1RAB9ACYP2C9NR4A2KCNK3 | |
| SCHEMBL3368576 | 0.80 | NPC1 (0.42) | NPC1RAB9ACYP2C9NR4A2EGLN1 | |
| SCHEMBL3367445 | 0.80 | APP (0.45) | EGLN1HPGDSMN1; SMN2MAPTTP53 | |
| SCHEMBL3369710 | 0.76 | SMN1; SMN2 (0.46) | NPC1RAB9ACYP2C9NR4A2HPGD | |
| SCHEMBL3367363 | 0.74 | NPC1 (0.65) | ROCK2NPC1RAB9ACYP2C9NR4A2 | |
| SCHEMBL3365520 | 0.74 | NPC1 (0.65) | NPC1RAB9ACYP2C9NR4A2KCNK3 | |
| SCHEMBL3367620 | 0.73 | APP (0.45) | NPC1RAB9AEGLN1 | |
| SCHEMBL3368584 | 0.72 | RIPK1 (0.41) | NPC1RAB9ANR4A2EGLN1SMN1; SMN2 | |
| SCHEMBL2433011 | 0.72 | NPC1 (0.53) | NPC1RAB9ACYP2C9NR4A2KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041133-B1 | DERIVATIVES OF IMIDAZO [1,2-A]PYRIDINE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-10-13 | — | — | EP | claimed |