Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365498 | 0.91 | ROCK2 (0.38) | EGLN1ROCK2NR4A2CYP2C9TP53 | |
| SCHEMBL3366289 | 0.79 | EGLN1 (0.56) | EGLN1NR4A2CYP2C9KCNH2DGAT1 | |
| SCHEMBL3368247 | 0.78 | EGLN1 (0.52) | EGLN1NR4A2CYP2C9KCNH2 | |
| SCHEMBL3368085 | 0.77 | EGLN1 (0.53) | EGLN1NR4A2CYP2C9KCNH2 | |
| SCHEMBL3367431 | 0.77 | EGLN1 (0.61) | EGLN1NR4A2CYP2C9KCNH2DGAT1 | |
| SCHEMBL3368804 | 0.74 | NR4A2 (0.60) | EGLN1NR4A2CYP2C9KCNH2DGAT1 | |
| SCHEMBL3368030 | 0.73 | NR4A2 (0.61) | EGLN1NR4A2CYP2C9KCNH2DGAT1 | |
| SCHEMBL3367445 | 0.72 | APP (0.45) | EGLN1TP53 | |
| SCHEMBL3365504 | 0.72 | EGLN1 (0.48) | EGLN1NR4A2CYP2C9 | |
| SCHEMBL3368576 | 0.72 | NPC1 (0.42) | EGLN1NR4A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041133-B1 | DERIVATIVES OF IMIDAZO [1,2-A]PYRIDINE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-10-13 | — | — | EP | claimed |