Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28561008 | 0.89 | ALDH1A1 (0.55) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL4463542 | 0.84 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL29031491 | 0.84 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL18703810 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| Alcohol SCHEMBL6858561 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL18703807 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL10577094 | 0.80 | ALOX15 (0.50) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL10577088 | 0.80 | ALOX15 (0.50) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL5646150 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10GLO1MAPT | |
| SCHEMBL5646160 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10GLO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113105475-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2021-07-13 | — | — | CN | disclosed |
| US-10822348-B2 | Inhibitors of Bruton's tyrosine kinase and methods of their use | JANSSEN PHARMACEUTICA NV (BE) | 2020-11-03 | — | — | US | disclosed |
| US-10800792-B2 | Inhibitors of Bruton's tyrosine kinase and method of their use | JANSSEN PHARMACEUTICA NV (BE) | 2020-10-13 | — | — | US | disclosed |
| US-10689396-B2 | Inhibitors of Bruton's tyrosine kinase and methods of their use | JANSSEN PHARMACEUTICA NV (BE) | 2020-06-23 | — | — | US | disclosed |
| US-20190284203-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-19 | — | — | US | disclosed |
| US-20190284204-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-19 | — | — | US | disclosed |
| EP-3386992-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | Janssen Pharmaceutica, N.V. (BE) | 2018-10-17 | — | — | EP | disclosed |
| WO-2018103058-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-14 | — | — | WO | disclosed |
| US-20170283431-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2017-10-05 | — | — | US | disclosed |
| US-20070213341-A1 | Spiroindolinone derivatives | CHEN LI | 2007-09-13 | — | — | US | disclosed |
| EP-0346107-B1 | Arylfluoroalkenamides and their use as pesticides | ROUSSEL UCLAF (FR) | 1995-09-13 | — | — | EP | disclosed |
| EP-0369762-B1 | Pesticides | ROUSSEL UCLAF (FR) | 1993-12-29 | — | — | EP | disclosed |
| WO-1993013062-A1 | HALOGENATED TETRAENYL PROSTAGLANDIN DERIVATIVES | G.D. SEARLE & CO. (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5202356-A | Insecticides, miticides | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-04-13 | — | — | US | disclosed |
| US-5180737-A | Insecticides, nematocides or anthelmintics | ROUSSEL UCLAF (FR) | 1993-01-19 | — | — | US | disclosed |
| US-5177251-A | Cytoprotective, antisecretory, side effect reduction | G. D. SEARLE & CO. (US) | 1993-01-05 | — | — | US | disclosed |
| US-5114940-A | Insecticides or anthelmintics from fused ring heterocycles containing amides or thioamides | ROUSSEL-UCLAF (FR) | 1992-05-19 | — | — | US | disclosed |
| EP-0369762-A1 | Pesticides | ROUSSEL-UCLAF (FR) | 1990-05-23 | — | — | EP | disclosed |
| EP-0346107-A2 | Arylfluoroalkenamides and their use as pesticides | ROUSSEL UCLAF (FR) | 1989-12-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689396-B2 | Inhibitors of Bruton's tyrosine kinase and methods of their use | ABL1, BTK, MYLK2 | ALDH1A1 3899/4885LMNA 912/4885HSD17B10 3153/4885 |
| US-20190284204-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE | ABL1, BTK, MYLK2 | ALDH1A1 4003/4885LMNA 1091/4885HSD17B10 3134/4885 |
| US-10822348-B2 | Inhibitors of Bruton's tyrosine kinase and methods of their use | ABL1, BTK, MYLK2 | ALDH1A1 3899/4885LMNA 912/4885HSD17B10 3153/4885 |
| US-20070213341-A1 | Spiroindolinone derivatives | MKI67, PKD1, RCC2 | ALDH1A1 65/4885LMNA 2188/4885HSD17B10 149/4885 |
| US-20170283431-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE | ABL1, BTK, MYLK2 | ALDH1A1 4003/4885LMNA 1091/4885HSD17B10 3134/4885 |
| US-20190284203-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE | ABL1, BTK, MYLK2 | ALDH1A1 4003/4885LMNA 1091/4885HSD17B10 3134/4885 |
| US-10800792-B2 | Inhibitors of Bruton's tyrosine kinase and method of their use | ABL1, BTK, MYLK2 | ALDH1A1 4003/4885LMNA 1091/4885HSD17B10 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.