Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14004136 | 0.84 | SCN9A (0.40) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL3583062 | 0.82 | PRKCA (0.41) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL13939958 | 0.80 | CNR2 (0.40) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL3395277 | 0.80 | PRKCA (0.36) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL4821691 | 0.80 | CNR2 (0.41) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL4821680 | 0.80 | CNR2 (0.40) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL3091875 | 0.79 | PRKCA (0.40) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL27713477 | 0.79 | PRKCA (0.40) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL3596844 | 0.79 | PRKCA (0.39) | SCN9APRKCAMMP12CYP3A4CYP2C19 | |
| SCHEMBL3362749 | 0.79 | PRKCA (0.39) | SCN9APRKCAMMP12CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987038-B1 | HCV NS5B INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2010-10-06 | — | — | EP | disclosed |
| US-7456165-B2 | HCV NS5B inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-25 | — | — | US | disclosed |
| EP-1987038-A2 | HCV NS5B INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007092888-A2 | HCV NS5B INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |
| US-20070185083-A1 | HCV NS5B Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185083-A1 | HCV NS5B Inhibitors | EIF2AK2, HAVCR2, EIF5B | SCN9A 1849/4885PRKCA 2318/4885MMP12 3825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.