Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 2/20 | 0.32 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368754 | 0.85 | AVPR1A (0.43) | NPY5RMALT1CYP17A1CYP1A2CYP21A2 | |
| SCHEMBL3366407 | 0.77 | FASN (0.37) | HTR2AHTR2CCYP2C19 | |
| SCHEMBL3365832 | 0.77 | FASN (0.37) | HTR2AHTR2CCYP2C19 | |
| SCHEMBL3366305 | 0.75 | CYP17A1 (0.33) | CYP11B2CYP19A1CYP17A1CYP11B1CYP1A2 | |
| SCHEMBL3465560 | 0.75 | KDM1A (0.39) | CYP11B2CYP19A1CYP17A1CYP11B1CYP1A2 | |
| SCHEMBL3368777 | 0.74 | KDM1A (0.37) | CYP11B2CYP19A1CYP17A1CYP11B1CYP1A2 | |
| SCHEMBL3617961 | 0.73 | CYP11B2 (0.37) | CYP11B2CYP19A1HTR2AHTR2CCYP17A1 | |
| SCHEMBL8246810 | 0.72 | CYP11B2 (0.36) | CYP11B2CYP19A1HTR2AHTR2CCYP17A1 | |
| SCHEMBL1128983 | 0.71 | CYP19A1 (0.37) | NPY5RCYP11B2CYP19A1HTR2AHTR2C | |
| SCHEMBL3367425 | 0.70 | FASN (0.38) | CYP11B2CYP19A1HTR2AHTR2CCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324235-B2 | Heterocyclic spiro-compounds | NOVARTIS AG (CH) | 2012-12-04 | — | — | US | disclosed |
| EP-2134720-B1 | HETEROCYCLIC SPIRO-COMPOUNDS | NOVARTIS AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| US-20100144774-A1 | HETEROCYCLIC SPIRO-COMPOUNDS | NOVARTIS AG (CH) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144774-A1 | HETEROCYCLIC SPIRO-COMPOUNDS | REN, NR3C2, CYP21A2 | NPY5R 792/4885CYP11B2 6/4885CYP19A1 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.