Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143188 | 0.87 | TDP1 (0.58) | SLC6A3TDP1TSHRMEN1KMT2A | |
| SCHEMBL2402612 | 0.83 | PPARD (0.43) | SLC6A4SLC6A3KCNH2MRGPRX4PTGDR2 | |
| SCHEMBL9974137 | 0.80 | TDP1 (0.72) | TDP1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3365226 | 0.79 | SLC6A4 (0.64) | SLC6A4SLC6A3KCNH2MRGPRX4AR | |
| SCHEMBL12160263 | 0.79 | TDP1 (0.57) | TDP1TSHRMEN1KMT2ATTR | |
| SCHEMBL3369984 | 0.76 | SLC6A4 (0.54) | SLC6A4SLC6A3KCNH2MRGPRX4AR | |
| SCHEMBL2401013 | 0.76 | PTGDR2 (0.48) | PTGDR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2117183 | 0.74 | TDP1 (0.79) | SLC6A3TDP1TSHRPTGDR2TTR | |
| SCHEMBL3365482 | 0.74 | TTR (0.70) | SLC6A4SLC6A3KCNH2MRGPRX4AR | |
| SCHEMBL2117921 | 0.74 | LMNA (0.59) | TDP1TSHRPTGDR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705047-B2 | Amidoacetonitrile derivatives | NOVARTIS AG (CH) | 2010-04-27 | — | — | US | disclosed |
| EP-1706373-B8 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2010-01-06 | — | — | EP | disclosed |
| EP-1706373-B1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-20070037881-A1 | N-[1-cyano-1-methyl-2-(5-cyano-2-{2,4-dichlorophenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide; etherification with a cyano-halobenzene in the presence of a basic catalyst; parasiticides, especially antihelmintics; veterinary medicine | ELANCO TIERGESUNDHEIT AG (CH) | 2007-02-15 | — | — | US | disclosed |
| EP-1706373-A1 | AMIDOACETONITRILE DERIVATIVES | Novartis AG (CH) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005058802-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037881-A1 | N-[1-cyano-1-methyl-2-(5-cyano-2-{2,4-dichlorophenoxy}-phenoxy)-ethyl]-4-trifluoromethoxybenzamide; etherification with a cyano-halobenzene in the presence of a basic catalyst; parasiticides, especially antihelmintics; veterinary medicine | CMA1, H1-2, H1-0 | SLC6A4 3459/4885SLC6A3 3589/4885KCNH2 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.