Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365789 | 0.80 | PDGFRB (0.81) | PDGFRBFLT3CSF1RKITSRC | |
| SCHEMBL3367321 | 0.77 | PRKDC (0.53) | PDGFRBILKAURKASRCFGFR1 | |
| SCHEMBL3364012 | 0.77 | PDGFRB (0.81) | PDGFRBFLT3CSF1RKITSRC | |
| SCHEMBL13841371 | 0.74 | NPC1 (0.57) | MEN1KMT2AILKSRCKDR | |
| SCHEMBL15630158 | 0.73 | MEN1 (0.64) | MEN1KMT2A | |
| SCHEMBL13114412 | 0.72 | PDGFRB (0.79) | PDGFRBFLT3CSF1RKITSRC | |
| SCHEMBL15483915 | 0.72 | ILK (0.55) | MEN1KMT2AILKAURKASRC | |
| SCHEMBL4507750 | 0.72 | KDM4E (0.61) | MEN1KMT2AILKSRCKDR | |
| SCHEMBL4690065 | 0.72 | KDM4E (0.54) | MEN1KMT2AILKSRCKDR | |
| SCHEMBL27111277 | 0.71 | PDGFRB (0.57) | PDGFRBFLT3CSF1RKITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309569-B1 | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors | MILLENNIUM PHARM INC (US) | 2010-10-06 | — | — | EP | claimed |
| EP-1309569-B1 | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors | MILLENNIUM PHARM INC (US) | 2010-10-06 | — | — | EP | disclosed |