Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 6/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ILK | Q13418 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398407 | 0.85 | PDGFRB (0.67) | PDGFRB | |
| SCHEMBL3364014 | 0.81 | PDGFRB (0.67) | AURKAPDGFRBFGFR1SRCGAK | |
| SCHEMBL7197973 | 0.80 | PDGFRB (0.54) | PRKDCAURKAHRH3PDGFRB | |
| SCHEMBL13841371 | 0.79 | NPC1 (0.57) | ILKALDH1A1FGFR1SRC | |
| SCHEMBL3367320 | 0.77 | PDGFRB (0.54) | AURKAILKPDGFRBFGFR1SRC | |
| SCHEMBL15483915 | 0.77 | ILK (0.55) | AURKAILKALDH1A1FGFR1SRC | |
| SCHEMBL5907744 | 0.77 | PDGFRB (0.66) | PDGFRBFGFR1SRCGAK | |
| SCHEMBL4690065 | 0.77 | KDM4E (0.54) | ILKALDH1A1FGFR1SRC | |
| SCHEMBL4507750 | 0.77 | KDM4E (0.61) | ILKALDH1A1SIGMAR1FGFR1SRC | |
| SCHEMBL3367276 | 0.76 | PDGFRB (0.66) | PDGFRBFGFR1SRCGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309569-B1 | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors | MILLENNIUM PHARM INC (US) | 2010-10-06 | — | — | EP | claimed |
| EP-1309569-B1 | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors | MILLENNIUM PHARM INC (US) | 2010-10-06 | — | — | EP | disclosed |