Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.58 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362825 | 0.89 | FFAR1 (0.54) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3365676 | 0.89 | FFAR1 (0.54) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3368579 | 0.89 | FFAR1 (0.54) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3367350 | 0.88 | FFAR1 (0.53) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3368340 | 0.88 | FFAR1 (0.53) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3363565 | 0.88 | PGR (0.57) | KDM4ESMN1; SMN2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL3365132 | 0.88 | L3MBTL1 (0.53) | KDM4ESMN1; SMN2CACNA1BCACNA1HL3MBTL1 | |
| SCHEMBL3368253 | 0.88 | FFAR1 (0.57) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3364934 | 0.87 | FFAR1 (0.52) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 | |
| SCHEMBL3366148 | 0.87 | FFAR1 (0.52) | KDM4ESMN1; SMN2CACNA1BCACNA1HFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| US-6683201-B2 | FOR THERAPY AND PROPHYLAXIS OF HYPERCHOLESTEROLEMIA, HYPERLIPEMIA, ARTERIOSCLEROSIS, VASCULAR DISEASES, MYCOSES, PARASITE INFECTIONS, GALLSTONES, TUMORS AND/OR HYPERPROLIFERATIVE DISORDERS, DIABETES | HOFFMANN-LA ROCHE INC. | 2004-01-27 | — | — | US | disclosed |
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-20020038025-A1 | Analine derivatives as OSC inhibitors | F.HOFFMANN-LA ROCHE AG (CH) | 2002-03-28 | — | — | US | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020038025-A1 | Analine derivatives as OSC inhibitors | LSS, CYP51A1, CYP46A1 | KDM4E 3964/4885SMN1; SMN2 4520/4885CACNA1B 2736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.