Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377862 | 0.85 | MAPT (0.53) | MAPTGAAALDH1A1MAPK1TDP1 | |
| SCHEMBL3368082 | 0.85 | TUBB4A (0.38) | MAPTGAAALDH1A1MAPK1TDP1 | |
| SCHEMBL3372538 | 0.83 | RAB9A (0.55) | MAPTGAAALDH1A1MAPK1TDP1 | |
| SCHEMBL3367765 | 0.81 | TUBB4A (0.38) | MAPTGAAALDH1A1MAPK1TDP1 | |
| SCHEMBL1379774 | 0.76 | RAB9A (0.63) | MAPTGAAALDH1A1MAPK1TDP1 | |
| SCHEMBL3370766 | 0.71 | CD274 (0.42) | GAAALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL3372486 | 0.69 | KDM4E (0.35) | ALDH1A1KDM4ETGFBR1ACVR1NPC1 | |
| SCHEMBL3371912 | 0.68 | FYN (0.34) | TGFBR1ACVR1NPC1LMNARECQL | |
| SCHEMBL5696184 | 0.68 | KMT2A (0.52) | MAPTGAAALDH1A1MAPK1MEN1 | |
| SCHEMBL3370431 | 0.68 | MAP3K11 (0.45) | TGFBR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628957-B1 | SULFOPYRROLES | TAKEDA PHARMACEUTICAL (JP) | 2010-09-29 | — | — | EP | claimed |