Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.59 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.59 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.59 |
| ▸ | PDE5A | O76074 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.51 |
| ▸ | SLC2A9 | Q9NRM0 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22498698 | 0.87 | ABCG2 (0.49) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| SCHEMBL5430100 | 0.86 | ESR1 (0.43) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| SCHEMBL19221566 | 0.83 | ABCG2 (0.75) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| SCHEMBL4758125 | 0.78 | ESR2 (0.39) | ESR1ESR2AKR1B1XDHMAPT | |
| SCHEMBL27950799 | 0.75 | TAS2R31 (0.39) | ESR1ESR2PTPN1MAPTKMT2A | |
| Sophoraflavanone B SCHEMBL14304885 | 0.74 | ESR1 (1.00) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| Sophoraflavanone B SCHEMBL1171435 | 0.74 | ESR1 (1.00) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| Sophoraflavanone B SCHEMBL147316 | 0.74 | ESR1 (1.00) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| Sophoraflavanone B SCHEMBL29396586 | 0.74 | ESR1 (1.00) | ESR1ABCG2ESR2AKR1B10AKR1B1 | |
| Sophoraflavanone B SCHEMBL1931652 | 0.73 | ESR1 (0.98) | ESR1ABCG2ESR2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893173-B1 | AMINO-OXO-INDOLE-YLIDENE COMPOUNDS FOR USE IN TREATING SCALP SKIN ITCHING | UNILEVER PLC (GB) | 2010-10-06 | — | — | EP | claimed |