Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372205 | 0.98 | HRH3 (0.39) | HTR1AHTR2ADRD2HRH3KCNH2 | |
| SCHEMBL3369491 | 0.85 | HTR2A (0.47) | HTR1AHTR2ADRD2HRH3HSP90AA1 | |
| SCHEMBL3369487 | 0.85 | HTR1A (0.39) | HTR1AHTR2ADRD2HRH3HSP90AA1 | |
| SCHEMBL3399689 | 0.83 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL3402918 | 0.82 | HRH3 (0.42) | HRH3KCNH2 | |
| SCHEMBL3372589 | 0.81 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL3403197 | 0.78 | HRH3 (0.42) | HRH3KCNH2 | |
| SCHEMBL3370860 | 0.78 | HRH3 (0.47) | HTR1AHTR2ADRD2HRH3KCNH2 | |
| SCHEMBL3372316 | 0.77 | HRH3 (0.39) | HRH3KCNH2 | |
| SCHEMBL3370584 | 0.77 | HRH3 (0.41) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | claimed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |