Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368835 | 0.96 | KDM4E (0.32) | CYP11B1CYP11B2KDM4EALDH1A1GLA | |
| SCHEMBL3397474 | 0.93 | CYP11B1 (0.33) | CYP11B1CYP11B2 | |
| SCHEMBL3368891 | 0.89 | CYP11B2 (0.33) | CYP11B1CYP11B2BACE1 | |
| SCHEMBL3368111 | 0.89 | CYP11B1 (0.33) | CYP11B1CYP11B2KDM4EALDH1A1GLA | |
| SCHEMBL3365502 | 0.85 | CYP11B1 (0.33) | CYP11B1CYP11B2 | |
| SCHEMBL3368990 | 0.83 | CYP11B1 (0.34) | CYP11B1CYP11B2 | |
| SCHEMBL3370381 | 0.81 | CYP19A1 (0.34) | CYP11B1CYP11B2BACE1 | |
| SCHEMBL3367425 | 0.80 | FASN (0.38) | CYP11B2ALDH1A1 | |
| SCHEMBL3401093 | 0.78 | CYP11B1 (0.34) | CYP11B1CYP11B2 | |
| SCHEMBL3366920 | 0.77 | CYP17A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324235-B2 | Heterocyclic spiro-compounds | NOVARTIS AG (CH) | 2012-12-04 | — | — | US | disclosed |
| EP-2134720-B1 | HETEROCYCLIC SPIRO-COMPOUNDS | NOVARTIS AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| US-20100144774-A1 | HETEROCYCLIC SPIRO-COMPOUNDS | NOVARTIS AG (CH) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144774-A1 | HETEROCYCLIC SPIRO-COMPOUNDS | REN, NR3C2, CYP21A2 | CYP11B1 4/4885CYP11B2 6/4885BACE1 1631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.