Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexane SCHEMBL1554946 | 0.97 | TSHR (0.44) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Dodecane SCHEMBL20299936 | 0.97 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Undecane SCHEMBL28267168 | 0.97 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Heptane SCHEMBL7940831 | 0.97 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Octane SCHEMBL20299932 | 0.97 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hexane SCHEMBL7875362 | 0.94 | TSHR (0.47) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Pentane SCHEMBL12271939 | 0.90 | TSHR (0.47) | TSHRTHRBALDH1A1LMNA | |
| Butane SCHEMBL3799640 | 0.79 | TSHR (0.33) | TSHRALDH1A1 | |
| Heptane SCHEMBL114510 | 0.78 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Decane SCHEMBL12471508 | 0.78 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
| US-7390927-B2 | Process for preparing 3-aminophenylacetylenes | FUJILFILM CORPORATION (JP) | 2008-06-24 | — | — | US | disclosed |
| US-20060224016-A1 | Process for preparing 3-aminophenylacetylenes | FUJI PHOTO FILM CO., LTD. | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289455-A1 | Monocarbams | MRPL21, C1R, C5AR1 | TSHR 2429/4885THRB 4267/4885DNM1 1550/4885 |
| US-20100160281-A1 | MONOCARBAMS | MRPL21, C1R, C5AR1 | TSHR 2429/4885THRB 4267/4885DNM1 1550/4885 |
| US-20060224016-A1 | Process for preparing 3-aminophenylacetylenes | NAT1, NAT10, KAT7 | TSHR 2511/4885THRB 4294/4885DNM1 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.