Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.98 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine SCHEMBL6238952 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL29245643 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL28185924 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL31298106 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL7532547 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL1314201 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL29846325 | 0.99 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL14109970 | 0.99 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL147362 | 0.99 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL24599520 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3682872-B1 | LIQUISOFT CAPSULES | PATHEON SOFTGELS INC (US) | 2024-01-03 | — | — | EP | claimed |
| EP-2968132-B1 | INJECTABLE MORPHINE FORMULATIONS | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2017-09-13 | — | — | EP | claimed |
| EP-1600154-B1 | Osmotic extended-release dosage form | ALZA CORP (US) | 2010-11-03 | — | — | EP | claimed |
| EP-0767663-B1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORP (US) | 2002-04-03 | — | — | EP | claimed |
| CN-111465396-B | Abuse-resistant morphine sulfate dosage form | 普渡制药公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-111465396-A | Abuse-resistant morphine sulfate dosage forms | 普渡制药公司 | 2020-07-28 | — | — | CN | disclosed |
| CN-109125254-A | Morphine composite, the kit comprising the morphine composite and its purposes | 费森尤斯卡比德国有限公司 | 2019-01-04 | — | — | CN | disclosed |
| US-6939538-B2 | Extended release analgesic for pain control | BIOMEDICAL RESEARCH MODELS, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| WO-2005016341-A1 | EXTENDED RELEASE ANALGESIC FOR PAIN CONTROL | BIOMEDICAL RESEARCH MODELS INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20030194438-A1 | Extended release analgesic for pain control | BIOMEDICAL RESEARCH MODELS, INC. | 2003-10-16 | — | — | US | disclosed |