Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.98 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine SCHEMBL6238952 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL29245643 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL3369901 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL28185924 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL31298106 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL7532547 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL29846325 | 0.99 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL14109970 | 0.99 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL147362 | 0.99 | OPRD1 (0.96) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL24599520 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12529695-B2 | Fentanyl analogue detection methods and kits thereof | VERITEQUE USA, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| CN-111465396-B | Abuse-resistant morphine sulfate dosage form | 普渡制药公司 | 2024-07-09 | — | — | CN | disclosed |
| US-20220390439-A1 | FENTANYL ANALOGUE DETECTION METHODS AND KITS THEREOF | VERITEQUE USA, INC. | 2022-12-08 | — | — | US | disclosed |
| EP-4049008-A1 | FENTANYL ANALOGUE DETECTION METHODS AND KITS THEREOF | Veriteque USA, Inc. (US) | 2022-08-31 | — | — | EP | disclosed |
| WO-2021081063-A1 | FENTANYL ANALOGUE DETECTION METHODS AND KITS THEREOF | VERITEQUE USA, INC. (US) | 2021-04-29 | — | — | WO | disclosed |
| US-10183001-B1 | Opioid and attention deficit hyperactivity disorder medications possessing abuse deterrent and anti-dose dumping safety features | PISGAH LABORATORIES, INC. (US) | 2019-01-22 | — | — | US | disclosed |
| US-20150133664-A1 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF | UNIV TEXAS (US) | 2015-05-14 | — | — | US | disclosed |
| CN-102307876-B | Synthesis of morphine-6-glucuronide or one of the derivatives thereof | SAI NUOFEI | 2014-12-10 | — | — | CN | disclosed |
| EP-2376496-B1 | SYNTHESIS OF MORPHINE-6-GLUCURONIDE OR OF A DERIVATIVE THEREOF | SANOFI SA (FR) | 2014-03-12 | — | — | EP | disclosed |
| WO-2013184902-A1 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-12-12 | — | — | WO | disclosed |
| US-4376825-A | ENZYME-BOUND LIGANDS WITH FREE REACTIVE SITES WHICH CAN BIND RECEPTORS | SYVA COMPANY (US) | 1983-03-15 | — | — | US | disclosed |
| US-4282325-A | FOR AMPLIFICATION IN ASSAYS | SYVA COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4203802-A | ENZYME BOUND TO AN ESTROGEN LIGAND | SYVA COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4190496-A | RECEPTOR, LIGAND, AND ENZYME-BOUND | SYVA COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4067774-A | Compounds for enzyme amplification assay | SYVA COMPANY (US) | 1978-01-10 | — | — | US | disclosed |
| US-4065354-A | HAPTENS | SYVA COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
| US-4064228-A | Antigens and immunoassays for morphine and related 3-oxybenzomorphan compounds | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4045440-A | ETHERIFICATION WITH METHYL IODIDE, OXIDATION WITH MANGANESE DIOXIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1977-08-30 | — | — | US | disclosed |
| US-3975237-A | LIGANDS | SYVA COMPANY (US) | 1976-08-17 | — | — | US | disclosed |
| US-3966556-A | Compounds for enzyme amplification assay methadone analogs | SYVA COMPANY (US) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183001-B1 | Opioid and attention deficit hyperactivity disorder medications possessing abuse deterrent and anti-dose dumping safety features | OPRM1, OPRD1, OPRL1 | OPRM1 1/4885OPRD1 2/4885OPRK1 5/4885 |
| US-12529695-B2 | Fentanyl analogue detection methods and kits thereof | CA13, CA2, CA12 | OPRM1 24/4885OPRD1 6/4885OPRK1 19/4885 |
| US-20150133664-A1 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.