Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793085 | 0.83 | ALDH1A1 (0.59) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL25700071 | 0.77 | ALDH1A1 (0.68) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28254875 | 0.77 | ALDH1A1 (0.68) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL15978923 | 0.75 | TDP1 (0.59) | TRPM8MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL315040 | 0.75 | HDAC8 (0.70) | KDM4EALDH1A1HDAC8 | |
| SCHEMBL29781370 | 0.75 | TDP1 (0.59) | TRPM8MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL29781372 | 0.75 | TDP1 (0.59) | TRPM8MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL18231413 | 0.75 | TDP1 (0.59) | TRPM8MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL1904111 | 0.72 | ALDH1A1 (0.70) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9056834 | 0.71 | CRBN (0.61) | NPC1RAB9APOLBMAPTCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990338-B1 | Biphenylcyclopropylamides as p-38 Kinase inhibitors | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| EP-1990338-A2 | Biphenylcyclopropylamides as p-38 Kinase inhibitors | Novartis AG (CH) | 2008-11-12 | — | — | EP | disclosed |